![](/__local/4/58/65/E6021171043FE6B82777A9B4EE8_5E10284E_21618.png)
姓名:詹冬玲
性别:女;
出生年月:1977年3月;
民族:汉族;
学历/学位:研究生/博士;
职称:副教授
联系方式:0431-84533312
E-mail:zdlgale@126.com
学习工作经历
2004/09-2010/07,吉林大学,酶工程国家重点实验室,博士,导师:冯雁
1999/09-2002/07,澳门太阳娱乐网站官网,动物科技学院,硕士,导师:秦贵信
1995/09-1999/07,澳门太阳娱乐网站官网,动物科技学院,学士
2015/06-2016/06,美国密歇根州立大学,微生物与生物化学实验室,访问学者
2014/09-至今,澳门太阳娱乐网站官网,tyc1286太阳集团,副教授
2005/07-2014/08,澳门太阳娱乐网站官网,tyc1286太阳集团,讲师
主要研究方向
食品微生物学与功能食品、分子生物学与食品生物技术、生物大分子的结构及空间改造。
代表著作与论文
1)Dongling Zhan, Shanshan Guan, Hanyong Jin, Weiwei Han*, Wang Song*. Stereoselectivity of phosphotriesterase with paraoxon derivatives: a computational study. J. Biomol. Struct. Dyn., 2016, 34(3): 600-11.
2)Dongling Zhan, Aixi Bai, Lei Yu, Weiwei Han*, Feng Yan*. Characterization of the PH1704 protease from pyrococcus horikoshii OT3 and the critical functions of Tyr120. Plos One, 2014, 9: e103902.
3)Dongling Zhan,Dongmei Wang,Weihong Min,Weiwei Han*.Exploring the Molecular Basis for Selective Binding of Homoserine Dehydrogenase from Mycobacterium leprae TN toward Inhibitors: A Virtual Screening Study. Int. J. Mol. Sci. 2014, 15(2): 1826-1841.
4)Dongling Zhan,Zhenhuan Zhou,Shanshan Guan,Weiwei Han*.The Effect of Conformational Variability of Phosphotriesterase upon N-acyl-L-homoserine Lactone and Paraoxon Binding: Insights from Molecular Dynamics Studies. Molecules 2013, 18(12):15501-15518.
5)Dongling Zhan,Jiao Sun,Yan Feng,Weiwei Han*.Theoretical Study on the Allosteric Regulation of an Oligomeric Protease from Pyrococcus horikoshii by Cl−Ion. Molecules 2014, 19(2): 1828-1842.
6)Dongling Zhan,Weiwei Han,Yan Feng*. Experimental and computational studies indicate the mutation of Glu12 to increase the thermostability of oligomeric protease from Pyrococcus horikoshii. Journal of Molecular Modeling. 2011,6:1241-1249.
7)Dongling Zhan, Han Bao, Shiyang Sun, Weiwei Han*,Jingsheng Liu*.Computational Studies of squalene synthase from Panax ginseng : homology modeling and virtual screening for a new inhibitor. Journal of Theoretical and Computational Chemistry. 2012,11:1101-1120.
8)Dongling Zhan,Wang song,Weiwei Han,Liu Jingsheng*.Study of Homology Modeling and High-throughout Screening of a New Inhibitor of Panax beta-As. Acta Chimica Sinica. 2012,70(3): 217-222.
9)Dongling Zhan, Gao Nan, Han Weiwei, Feng Yan*.Quantum Chemistry Calculation of Thermophilic Protease PH1704 Allosteric Center and Mutant Dynamics. Chemical Journal of Chinese Universities.2014,35(1):146-153.
10)Dongling Zhan, Ago Nan, Han Weiwei, Feng Yan*.Molecular Docking and Dynamics Simulation Improving Thermophilic Protease Activity of PhpI. Chemical Journal of Chinese Universities.2013,34(3):628-633.
11) Han Wei-wei,Dongling Zhan, Zhao Xi,Wang Song*. Computational Investigation on the Ethylene-induced Esterase from Citrus Sinensis. Chemical Research in Chinese Universities. 2010,26(1):128-135.
12)Wei-Wei Han,Dong-ling Zhan, Quan Luo,Yi-Han Zhou, Yuan Yao, Ze-Sheng Li, Yan Feng*.The substrate specificity and the catalytic mechanism of N-carbamyl-D-amino acid amidohydrolase: A theoretical investigation. Chemical Physics Letters. 2009,472:107-112.
13)詹冬玲,韩葳葳,刘景圣*.嗜热酯酶EstTs1的remote homology modeling及分子对接的研究.吉林大学理学版.2011,6:1131-1134.
14)詹冬玲,白挨玺,白鹤,韩葳葳,冯雁*.嗜热菌Pyrococcus horikoshii OT3蛋白酶基因的原核表达、纯化和性质表征.吉林大学理学版.2010,6:1131-1135.
15)詹冬玲,韩葳葳,刘景圣*.角鲨烯合成酶抑制剂的高通量虚拟筛选的研究.吉林大学理学版.2012,3:361-364.
16)詹冬玲,任玉雪,李克剑,闵伟红,刘 洋,张英文,刘景圣*.磷酸三酯酶突变体H23A的真核表达及性质表征.食品科学.2013,34(23): 250-255.
主要科研项目
1、吉林省重点科技攻关项目“多元复合RS制备及其健康食品研究与开发”,主持;
2、吉林省重点科技攻关项目“新型有机磷水解酶的分子设计及反应机理研究”,第1完成人。
奖励及其它
1)刘景圣、郑鑫、闵伟红、张大力、王玉华、蔡丹、郑明珠、赵英明、宋菊英、丁健、姜茂君、方丽、詹冬玲、王志同,蜜环菌深层发酵技术在功能性食品中的应用研究,吉林省科技厅,吉林省科技进步奖,一等奖,2010
2)韩葳葳、詹冬玲、王嵩、罗全,几类重要酶的同源模建、分子对接及反应机理,吉林省科学技术协会,吉林省自然科学学术成果奖,二等奖,2011
3)闵伟红、张大力、李鸿梅、刘景圣、杨栋梁、郑明珠、詹冬玲、蔡丹、刘鹤、郑鸿雁、方丽、高雅文、谷春梅,玉米淀粉生物转化关键技术研究与产品开发,吉林省科技厅,省科技进步奖,二等奖,2012
4)詹冬玲,韩葳葳,邵洪泽,酶的分子模拟与结构改造,吉林省科学技术协会,吉林省自然科学学术成果奖,三等奖,2013
教学工作(主编教材、主讲课程)
主讲:“食品生物化学”本科生课程,“高级食品生物化学”研究生课程。